Detecting differentially expressed genes in microarray experiments is a topic that has been well studied in the literature. Many hypothesis testing methods have been proposed that rely on strong distributional assumptions for the gene intensities. However, the shape of microarray data may vary...

The development of new technologies to measure gene expression has been calling for statistical methods to integrate findings across multiple-platform studies. A common goal of microarray analysis is to identify genes with differential expression between two conditions, such as treatment versus...

This paper addresses the problem of portfolio selection under a multifactor asset return model, using Bayesian analysis to deal with uncertainties in parameter estimation and model specification. These sources of error are ignored in the classical mean-variance method. We apply two approaches:...

Statistical modeling and inference problems with sample sizes substantially smaller than the number of available covariates are challenging. This is known as large p small n problem. Furthermore, the problem is more complicated when we have multiple correlated responses. We develop multivariate...

In this work, the authors propose a novel method called online variable kernel estimation of the probability density function (pdf). This new online estimator combines the characteristics and properties of two estimators namely nearest neighbors estimator and the Parzen-Rosenblatt estimator....

A challenge in microarray data analysis concerns discovering local structures composed by sets of genes that show homogeneous expression patterns across subsets of conditions. We present an extension of the mixture of factor analyzers model (MFA) allowing for simultaneous clustering of genes and...

A paired data set is common in microarray experiments, where the data are often incompletely observed for some pairs due to various technical reasons. In microarray paired data sets, it is of main interest to detect differentially expressed genes, which are usually identified by testing the...

We present a new approach to molecular classification based on mRNA comparisons. Our method, referred to as the top-scoring pair(s) (TSP) classifier, is motivated by current technical and practical limitations in using gene expression microarray data for class prediction, for example to detect...