The article documents and analyzes patients organizations- and groups of activists’ “evidence-based activismâ€, and the compound dynamic interplay between politics of illness and politics of knowledge it entails in the four condition areas studied: ADHD, Alzheimer, rare diseases...

From a perspective informed by science and technology studies, the authors propose to establish a general diagnosis on the regulation of publication practices and suggest methods of analysis by drawing on old and recent cases that have been questionning research integrity.

Introduces the notions of ontological uncertainty and of problematization sites for the analysis of innovation and discusses political implications.

Analyses the role of European patients’ organizations in the process of Europeanization of healthcare policies by exploring the types of organizations constituted by European patients’ organizations and the form of activism they develop.

Clarifies the potentials of the notion of exploration for the analysis of the uncertain and collective nature of entrepreneurship, and provides detailed examination of a case study on a French academic spin-off.