The article deals with an optimal response-adaptive design for allocating patients among two competing treatments in a phase III clinical trial. An optimal response-adaptive target is developed for a general class of response distributions subject to two clinically relevant constraints. Various...

Optimal response-adaptive designs have been studied by various authors in the context for allocating patients among two competing treatments in a phase III clinical trial. However, depending on the variabilities of the responses, most of these designs may allocate a smaller number of patients to...

In the present article, we develop some asymptotically power on partially sequential nonparametric tests for monitoring structural changes. Our test procedures are based on Wilcoxon score. We use the idea of curved stopping boundaries. We derive some exact results and perform simulation studies...