Tibshirani, Robert; Efron, Brad - In: Statistical Applications in Genetics and Molecular Biology 1 (2007) 1, pp. 1-1
In microarray studies, an important problem is to compare a predictor of disease outcome derived from gene expression levels to standard clinical predictors. Comparing them on the same dataset that was used to derive the microarray predictor can lead to results strongly biased in favor of the...