Objective:Objective: The study aimed to conduct a systematic literature search to identify health state utilities for weight change in type 2 diabetes mellitus (T2DM) and to review those values for appropriateness for inclusion in a submission to the National Institute for Health and Clinical...

Intravenous esomeprazole (Nexium) is approved in Europe for the prevention of rebleeding following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers. In a pivotal clinical trial, patients with peptic ulcer bleeding and high-risk stigmata who received intravenous esomeprazole...

Background: Simulation techniques are well suited to modelling diseases yet can be computationally intensive. This study explores the relationship between modelled effect size, statistical precision, and efficiency gains achieved using variance reduction and an executable programming language....

Migraine is a highly prevalent, nonfatal disorder typically characterized by recurrent episodes of headache associated with such symptoms as nausea, vomiting, photophobia, phonophobia and impaired functioning. The attacks may be infrequent and relatively mild; more often they are frequent, severe...

Depression is a common, serious illness that affects millions of individuals, most often in their prime years of productivity. There is strong evidence that depression is as debilitating as most other general medical conditions and results in increased general medical resource utilisation. The...

Chronic diseases such as arthritis and related conditions have no `cure', and thus require ongoing management. The long term nature of chronic disease gives the individual a crucial role, if not the most crucial role, in managing their condition. Day-to-day self-management is extremely important...

Prevention and long term disease management have been added relatively recently as `new' components of a modern day total healthcare services system. The goal of primary prevention, which includes medical preventive services, lifestyle interventions and screening services, is to maintain a...