major depression in the UK NHS. Design, patients and interventions: A decision-tree model for the treatment of major … depression was constructed by interviewing UK GPs and psychiatrists (as part of a Delphi panel). An important part of the tree …-effective option compared with the SSRIs and TCAs when used as a first-line drug for depression in primary care in the UK. As this is a …

). Assessments, including clinical evaluation [Montgomery-Asberg Depression Rating Scale (MADRS), Clinical Global Impressions (CGI …, whether related to depression or not. There were no significant differences between groups for work or productivity losses …

, healthcare cost burden and productivity gains for patients successfully treated for depression. Most model-based studies …

Worldwide, major depression is the leading cause of years lived with a disability, and the fourth cause of disability …-adjusted life years. Depression is second only to hypertension as the most common chronic condition encountered in general medical … practice. Unfortunately, despite the high prevalence of depression, under-recognition and under-treatment are common …

serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) on the basis of mean depression rating scale scores. Data from …-effective alternative to amitriptyline and fluoxetine for the treatment of depression. Mirtazapine also has similar effects to SSRIs on …

were illustrated using a Markov model of depression. Main outcome measures and results: The application of the refined …

. Patient-reported outcomes (EuroQOL questionnaire, Quality of Life Depression Scale), use of medical services and absence from …