depression, the evidence for fluoxetine and for the selective serotonin reuptake inhibitors in general suggest at best a modest …Fluoxetine continues to be remarkably successful; greater volumes of this drug are sold than for any other … fluoxetine, and highlight the response of the sponsor in the development of subsequent drugs for CNS disorders. …

Depression is a very costly chronic disease. An important cost driver is treatment failure caused by patient … medication switching contribute to the high cost of treatment. With the epidemiological data for depression demonstrating a rise … in both incidence and prevalence over the last 20 years, and the fact that many of the newer antidepressants will see …

Objective: To estimate the cost effectiveness of different classes of antidepressants in the UK National Health Service …) reuptake inhibitor (SNRI) venlafaxine was compared with that of selective serotonin reuptake inhibitors (SSRIs) and tricyclic … antidepressants (TCAs) in patients with major depressive disorder (MDD). A meta-analysis determined the clinical success rate, and a …

Background and Objective: A growing body of literature on the economics of depression concludes that this illness has … depression also result in elevated rates of chronic absenteeism that manifest in the form of workplace disability. Design and … manufacturer, we measured the extent of disability before and after initial treatment for major depression. Participants: 1260 …

prescribed antidepressants. Patients treated with SSRIs suffered from less severe depression than those treated with tricyclic …Objective: To describe the pharmacological treatment for major depression under the conditions of routine Italian …: This was a prospective multicentre observational study designed to evaluate the economics of treatment of major depression …

compared the cost effectiveness of sertraline, citalopram, escitalopram and fluoxetine with paroxetine in elderly depressed … sertraline, citalopram, escitalopram or fluoxetine was more cost effective than paroxetine was 96.7%, 77.6%, 96.3% and 97 … of generic paroxetine, and that, after the entry of generic paroxetine, citalopram and escitalopram were dominated by …

the cost effectiveness of antidepressant drugs, with special emphasis on comparing third-generation antidepressants (TGAs …) with tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Information from the collected … the various classes of antidepressants. Factors examined included direct and indirect costs, treatment endpoints …

Depression is the most common mental health disorder and is recognized as a chronic disease characterized by multiple … depression interventions, comparatively little attention has been paid to issues around modelling studies with a focus on … literature on recently published model-based cost-utility studies of depression. Taking depression as an illustrative example …

While fluoxetine is considerably more expensive than tricyclic antidepressants (TCAs), some previous studies have … suggested that general medical expenditures are lower among patients treated with fluoxetine. In this study, computerised …-care patients beginning antidepressant treatment with fluoxetine or one of 2 TCAs, imipramine or desipramine. Comparison was based …

Pharmacotherapeutic advances in the treatment of depression have included the development of the selective serotonin … reuptake inhibitors (SSRIs), thereby providing alternatives to tricyclic antidepressants. Concurrent with these events have … treatment of depression within the context of clinical practice as compared with RCTs, meta-analyses and DAMs. The portfolio of …