prevention of vertebral fractures in postmenopausal women with osteoporosis. Design: A retrospective, incremental cost … formed the efficient frontier in the following order: 1. calcium -> no therapy; 2. ovarian hormone therapy (OHT) -> calcium … -> no therapy [166 Canadian dollars ($Can)]; 3. OHT -> etidronate -> calcium -> no therapy ($Can2331); and 4. OHT …

Osteoporosis constitutes a major public health problem through its association with fractures at several skeletal sites …-effective use of these pharmacological agents has become a focus for health economic research in osteoporosis. Such research will …

Specific regulatory guidelines dictate that developing a new drug for osteoporosis will be significantly more expensive … $US86 million for non-estrogen osteoporosis compounds following a minimum programme designed to gain indications for both … investment on an osteoporosis drug will be a minimum of $US95 million greater per launched compound. Many ongoing osteoporosis …

Denosumab in Osteoporosis every 6 Months) trial. It is becoming increasingly important to evaluate not only the therapeutic …). Analyses were performed in populations (aged ≥60 years) in which osteoporosis medications are currently reimbursed in many … appears to have the potential to become a first-line treatment for post-menopausal women with osteoporosis. However, further …

Postmenopausal osteoporosis is characterized by an increased rate of bone turnover accompanied by a reduction in bone …, osteoporosis. Alendronate produces sustained increases in BMD and reductions in bone turnover from baseline, and reduces the risk … of vertebral, hip, wrist, and other fractures in women with postmenopausal osteoporosis. It also prevents bone loss, and …

A disconnection exists between our understanding of osteoporosis diagnosis/treatment and our ability to provide optimal … the attitude that osteoporosis is a disease worthy of management), direction (focusing on the ultimate goal of … osteoporosis diagnosis and management, i.e. reduction in fracture), and flow (making it easy to do the right thing, i.e. taking the …

Background: The aging of the population is likely to increase the number of osteoporosis-related fractures, such as hip … interest. Objective: The aim of this study was to determine the cost effectiveness of preventive services for osteoporosis …

The economic burden associated with osteoporosis is considerable. As such, cost-effectiveness analyses are important … of treating post-menopausal osteoporosis with bisphosphonates and identify the key factors that influence the cost …-menopausal osteoporosis in the Swiss setting. Outcomes were compared with similar studies in Western European countries. Three cost …