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Worldwide, major depression is the leading cause of years lived with a disability, and the fourth cause of disability …-adjusted life years. Depression is second only to hypertension as the most common chronic condition encountered in general medical … practice. Unfortunately, despite the high prevalence of depression, under-recognition and under-treatment are common …
Persistent link: https://www.econbiz.de/10005404970
use of generics after patent expiry for enalapril, fluoxetine and ranitidine and the subsequent changes, if any, in the … after patent expiry. Significant differences in the trend lines were found for enalapril and fluoxetine. Conclusions …
Persistent link: https://www.econbiz.de/10005243067
Evidence produced by multinational trial-based cost-effectiveness studies is often used to inform decisions concerning the adoption of new healthcare technologies. A key issue relating to the use of this type of evidence is the extent to which trial-wide economic results are applicable to every...
Persistent link: https://www.econbiz.de/10008725811
Background: Cost-effectiveness models should always be amendable to updating once new data on important model parameters become available. However, several methods of synthesizing data exist and the choice of method may affect the cost-effectiveness estimates. Objectives: To investigate the...
Persistent link: https://www.econbiz.de/10010614313
Methods for determining sample size requirements for cost-effectiveness studies are reviewed and illustrated. Traditional methods based on tests of hypothesis and power arguments are given for the incremental cost-effectiveness ratio and incremental net benefit (INB). In addition, a full...
Persistent link: https://www.econbiz.de/10010614384
Recently, health systems internationally have begun to use cost-effectiveness research as formal inputs into decisions about which interventions and programmes should be funded from collective resources. This process has raised some important methodological questions for this area of research....
Persistent link: https://www.econbiz.de/10005590356
The principal aim of this article is to share lessons learned by the authors while conducting economic evaluations, using clinical trial data, of mental health interventions. These lessons are quite general and have clear relevance for pharmacoeconomic studies. In addition, we explore how net...
Persistent link: https://www.econbiz.de/10005449265
The application of Bayesian statistical analyses has been facilitated in recent years by methodological advances and an increasing complexity necessitated within research. Substantial debate has historically accompanied this analytic approach relative to the frequentist method, which is the...
Persistent link: https://www.econbiz.de/10005404905
Depression is the most common mental health disorder and is recognized as a chronic disease characterized by multiple … depression interventions, comparatively little attention has been paid to issues around modelling studies with a focus on … literature on recently published model-based cost-utility studies of depression. Taking depression as an illustrative example …
Persistent link: https://www.econbiz.de/10010548284
Background: Previous research has shown that a manufacturer's promotional strategy for a brand name drug is typically affected by generic entry. However, little is known about how newer strategies to extend patent life, including product reformulation introduction or obtaining approval to market...
Persistent link: https://www.econbiz.de/10005243133