fracture is very high (40-50% in women and 13-22% in men). Fractures are associated with significant mortality and morbidity … ibandronate) are indicated for the treatment and prevention of osteoporosis but are costly compared with other treatments, such as … studies investigating bisphosphonates in women with low BMD and no previous fracture, one study of bisphosphonates in women …

-ray absorptiometry (DXA). Those with an absolute 10-year fracture risk >=30% are treated with bisphosphonates such as alendronate or … correctly diagnosed by pre-tests and DXA as having a 10-year fracture risk of >=30% was estimated for different age groups (50 …

fracture by 40%, and reduced the incidence of clinical vertebral fracture by 69%. An indirect treatment comparison was used to … derive adjusted relative risk (RR) estimates for different types of fracture for each comparator versus placebo. The RRs (95 …% CI) applied for denosumab were 0.316 (0.208, 0.478) for clinical vertebral fracture, 0.605 (0.373, 0.983) for hip …

Osteoporosis constitutes a major public health problem through its association with fractures at several skeletal sites …, most notably the hip, wrist and vertebra. The lifetime risk of hip fracture in White women and men in the UK from age 50 …. Methods of measuring bone density provide useful clinical tools for the assessment of future fracture risk, and a number of …

significant. While studies have reported the incremental or attributable costs of osteoporosis-related fracture, data on the …Background:Background: Osteoporosis is a common condition and the economic burden of osteoporosis-related fractures is … economic impact of osteoporosis-related fractures in commercial health plan populations are limited. Abstract: Objective …

used and the fracture assessment. Despite the variability in estimates, the literature indicates that osteoporosis … osteoporosis-related fractures in the US. We conducted a systematic literature review of published studies that used claims … databases and economic studies reporting costs associated with osteoporosis-related fractures in the US. Studies published …

Background: The Fracture Intervention Trial (FIT) demonstrated that the bisphosphonate alendronate reduces the risk of … hip, spine and wrist fracture in osteoporotic women by approximately one half. Objective: To use data from FIT to conduct …, comparable in relative fracture risk to the women enrolled in the FIT vertebral fracture arm (i.e. age 71 years with low bone …

Background: Osteoporosis is a condition marked by low bone mineral density and the deterioration of bone tissue. One of … the main clinical and economic consequences of osteoporosis is skeletal fractures. Objective: To assess the healthcare and …) and Medicare (aged ≥65 years) patients with osteoporosis (ICD-9-CM code: 733.0x) were identified during 1999-2006 using …

significantly reduce the risk of hip, vertebral and non-vertebral fractures in the FREEDOM (Fracture REduction Evaluation of … Denosumab in Osteoporosis every 6 Months) trial. It is becoming increasingly important to evaluate not only the therapeutic …). Analyses were performed in populations (aged ≥60 years) in which osteoporosis medications are currently reimbursed in many …