Comparative risk projects can provide broad policy guidance but they rarely have adequate scientific foundations to support precise risk rankings. Many extant projects report rankings anyway, with limited attention to uncertainty. Stochastic uncertainty, structural uncertainty, and ignorance are...

The forms and contexts in which risk analytical methods can provide useful inputs to policy decisions remains an open question. This paper assesses the role of uncertainty in cost- effectiveness estimation using the example of life-saving interventions available to regulators in the United...