Background: Previous research to develop a new generic paediatric health-related quality of life (HR-QOL) measure generated 11 dimensions of HR-QOL, covering physical, emotional and social functioning. These dimensions and their response scales were developed from interviews with children. Some...

External genital warts (EGW) are a sexually transmitted infection caused by various strains of human papillomavirus (HPV). Several studies have described the direct and indirect costs of EGW, while others have reported on the burden of EGW in terms of the impact on the quality of life (QOL) of...

When going 'beyond the patient', to measure QALYs for unpaid carers, a number of additional methodological considerations and value judgements must be made. While there is no theoretical reason to restrict the measurement of QALYs to patients, decisions have to be made about which carers to...

Background: Many clinical trials that generate evidence on the quality-of-life (QOL) improvements provided by new health technologies do not incorporate a preference-based generic measure, but generate only disease-specific data. However, in order to meet the information needs of regulators such...

Background:Background: Many statistical analyses, clinical trials and cost-utility analyses designed to measure the impact of a particular disease on utility scores often overlook the important influence of co-morbidity burden. Abstract: Objectives:Objectives: This study aims to examine the...

Background:Background: Patient-reported outcomes (PRO) measures should be valid and accessible to a wide audience. Abstract: Objective:Objective: Cognitive item testing and readability studies were conducted to evaluate how adult headache sufferers (N - 9) understood and responded to the...

Background: Many patient-reported outcomes (PRO) instruments are scored by averaging or summing Likert category values over all items or domains of the elicitation instrument, yielding domain-specific scores or a total score for the entire instrument. Objective: To evaluate differences between...

Background: Preference-based measures of health (PBMH) provide 'preference' or 'utility' weights that enable the calculation of QALYs for the economic evaluations of interventions. The Diabetes Utility Index (DUI) was developed as a brief, self-administered, diabetes mellitus-specific PBMH that...

Objectives: To assess the effects of premenstrual disorders on health-related quality of life (HR-QOL), hobbies and social activities, and relationships with others in the multinational IMPACT study. Methods: Women aged 15-45 years were screened for suspected premenstrual dysphoric disorder...