There are two topics in this dissertation. The first topic is 'Smoothing Parameter Selection in Nonparametric Generalized Linear Models via Sixth-order Laplace Approximation' and the second topic is 'Smoothing Spline-based Score Tests for Proportional Hazards Models'.We present a new approach...

We consider the design problem for the estimation of several scalar measures suggested in the epidemiological literature for comparing the success rate in two samples. The designs considered so far in the literature are local in the sense that they depend on the unknown probabilities of success...

The purpose of this work is the exploration of statistical methods and evaluation criteria of relational technology diversification of technical-scientific services provided by the infrastructure of Brazilian scientific and technological research. The technical and scientific services of a...

Abstract In a recent article, VanderWeele and Vansteelandt (American Journal of Epidemiology, 2010, 172:1339–1348) (hereafter VWV) build on results due to Judea Pearl on causal mediation analysis and derive simple closed-form expressions for so-called natural direct and indirect effects in an...

Abstract Matched pairs appear frequently in studies of the association between a dichotomous exposure and a dichotomous outcome. The standard conditional logistic regression estimator of the common odds ratio is consistent, but uses only information from the doubly discordant pairs. To gain...