The nucleosome is the fundamental packing unit of DNA in eukaryotic cells, and its positioning plays a critical role in regulation of gene expression and chromosome functions. Using a recently developed chemical mapping method, nucleosomes can be potentially mapped with an unprecedented...

This paper is concerned with hierarchical clustering of long binary sequence data. We propose two alternative improvements of the EM algorithm used in Chen and Lindsay (2006). One is the FixEM. It is just the regular EM but we no longer update the weights πs used in the ancestral mixture...

General strategies for constructing second order efficient robust distances from suitable properties of the residual adjustment functions (RAF) are discussed. Based on those properties families of estimators are constructed using the truncated polynomial, negative exponential and sigmoidal...

Lindsay (1994) provided a general set up in discrete models for minimum disparity estimation. Such a set up eludes us in continuous models. We provide such a general result and hence fill up a major gap in the literature.

In this paper we develop some natural “goodness-of-fit” tests for the Gompertz growth curve model (GGCM) based on the empirical estimate of relative growth rate (RGR). Existing approaches of goodness-of-fit tests for growth curve models are mainly based on finite differences of the size data...