Xiong, Chengjie; Luo, Jingqin; Gao, Feng; Morris, John C. - In: Computational Statistics & Data Analysis 69 (2014) C, pp. 101-113
Disease-modifying (DM) trials on chronic diseases such as Alzheimer’s disease (AD) require a randomized start or withdrawal design. The analysis and optimization of such trials remain poorly understood, even for the simplest scenario in which only three repeated efficacy assessments are...