A number of factors have been proposed that may affect the capacity for an evolutionary system to generate adaptation. One that has received little recent attention among biologists is linkage patterns, or the ordering of genes on chromosomes. In this study, a simple model of genetic...

The administration of a genetically engineered defective interfering virus (DIV) that interferes with HIV-1 replication has been proposed as a therapy for HIV-1 infection and AIDS. The proposed interfering virus, which is designed to superinfect HIV-1 infected cells, carries ribozymes that...

(Paper 1) A spacially extended model of the collective behavior of a large number of locally acting organisms is proposed in which organisms move probabilistically between local cells in space, but with weights dependent on local morphogenetic substances, or morphogens. The morphogens are in...

Genetic Algorithms (GAs) and heuristic search are shown to be structurally similar. The strength of the correspondence and its practical consequences are demonstrated by considering the relationship between fitness functions in GAs and the heuristic functions of AI. By examining the extent to...

In this paper the relationship between evolution and entropy is described for a model of self-reproducing parallel computation. As was recently shown, [5], the performance of some types of parallel computation can be increased through a process analogous to evolution by natural selection. The...

We present a gene-culture coevolutionary model for brother-sister mating in the human. It is shown that cultural--as opposed to innate--determination of mate preference may evolve, provided the inbreeding depression is sufficiently high. At this coevolutionary equilibrium, sib mating is avoided...

Why are some ecosystems so rich, but yet contain so many rare species? High species diversity, together with rarity, is a general trend in neotropical forests and coral reefs. But the origin of such diversity and the consequences of food web complexity in both species abundances and temporal...

This paper presents a model of a firm preparing to launch a product into a market where consumer preferences change over time and cannot be directly observed. Market research is used in order to determine what type of product to produce. The employees making decisions based on the market...

Communication plays a vital role in the organization and operation of biological, computational, economic, and social systems. Agents often base their behavior on the signals they receive from others and also recognize the importance of the signals they send. Here we develop a framework for...

This paper presents a Bayesian "correction" to the familiar quadratic loss bias-plus-variance formula. It then discusses some other loss-function-specific aspects of supervised learning. It ends by presenting a version of the bias-plus-variance formula appropriate for log loss.