A new approach to drug discovery is based on the generation of high diversity libraries of DNA, RNA, peptides or small molecules. Search of such libraries for useful molecules is an optimization problem of high-dimensional molecular fitness landscapes. We utilize a spin-glass-like model, the NK...

The Utilization of high diversity molecular libraries for dtug discovery in now becoming a cnetrally important and developing set of technologies, (Balliver and Kauffman 1986, 1989,1990, Geysen et. al 1987). Om he pase decade, efforts focused on two approaches: The first is ``genetic'' and based...

We argue that in classical and quantum theories of gravity the configuration space and Hilbert space may not be constructible through any finite procedure. If this is the case, then the ``problem of time'' in quantum cosmology may be a pseudo-problem, because the argument that time disappears...

The theory of autocatalytic binary ligation is reviewed within the context of a rigorously applied Michaelis-Menten quasi-steady-state approximation to obtain explicit analytical results describing time-course data from experiments. A detailed protocol for the step-wise elucidation of a minimal...

We demonstrate the existence of a phase transition in combinatorial optimization problems. For many of these problems, as local search algorithms are parallelized, the quality of solutions first improves and then sharply degrades to no better than random search. This transition can be...