The first objective of this book is to provide an up-to-date exposition of the techniques that are available for optimizing complex systems and to do so in a way that unifies the theory of nondifferentiable and two-level mathematical programming. The second objective is to highlight the most...

Coordinated services and virtual medicine are the two innovative concepts being employed in the transformation from provider-centered care to patient-centered care. In this paper, we combine these two concepts to study a coordinated scheduling problem with both virtual medicine patients (VM...

The primary purpose of this paper is to validate a clustering procedure used to construct contiguous vehicle routing zones (VRZs) in metropolitan regions. Given a set of customers with random demand for pickups and deliveries over the day, the goal of the design problem is to cluster the...

This paper presents a new model and solution methodology for the arrival slot reallocation problem faced by airlines when responding to a ground delay program (GDP). The objective is to reassign the flights in the GDP to time slots made available by the Federal Aviation Administration (FAA) such...

The paper presents a three-phase procedure for clustering a large number of data points subject to both configuration and resource constraints. Motivated by the desire of a shipping carrier to reduce its fixed costs, the problem is to construct a set of compact work areas for regional pickup and...