Showing 41 - 50 of 47,367
Objective: To simulate the treatment of postmenopausal women with advanced breast cancer from second-line hormone therapy to death, and to generate estimates of the cost and effectiveness of letrozole and megestrol in order to determine the incremental cost effectiveness of letrozole, expressed...
Persistent link: https://www.econbiz.de/10005449176
Objective: We constructed a UK-based decision model of palliative care for terminally ill cancer patients who were switched from a weak to a strong opioid so that the expected direct healthcare costs in the UK could be estimated from the time a patient commenced a strong opioid until death....
Persistent link: https://www.econbiz.de/10005449313
-for-service Medicare beneficiaries, we document the association between mortality risk and end-of-life medical spending. Mortality risk at … found that, among decedents, end-of-life spending is inversely related to predicted mortality risk, ranging from $US23 …_000 for decedents with mortality risk in the interval 0.00-0.05 to $US16_000 for decedents with mortality risk >0.25 (1999 …
Persistent link: https://www.econbiz.de/10005404761
Objective: In patients with amyotrophic lateral sclerosis, long term treatment with riluzole has been reported to improve survival or tracheostomy-free survival in comparison with placebo. We conducted a pharmacoeconomic analysis for estimating the cost per life-year gained using this drug....
Persistent link: https://www.econbiz.de/10005404893
Vinorelbine is a semisynthetic vinca alkaloid that is effective against advanced non-small cell lung cancer (NSCLC). Myelosuppression is the primary dose-limiting toxicity; vinorelbine is otherwise relatively well tolerated. Two studies assessed the cost effectiveness of vinorelbine with or...
Persistent link: https://www.econbiz.de/10005590381
Objective. Patients with pancreatic cancer have only short survival after diagnosis, irrespective of treatment. The aim of this study was to perform a health economic evaluation of present standard treatment (in most cases, palliative treatment in combination with best supportive care) versus...
Persistent link: https://www.econbiz.de/10005590429
Objective: To identify any changes in expenditures and in morbidity and mortality with the progression of treatment of …, laboratory and prescription costs, and morbidity and mortality rates. Main outcome measures and results: The 3 periods had … immunosuppression (defined as CD4+ lymphocyte counts <500 cells/mm3). Morbidity and mortality were not changed by the addition of dual …
Persistent link: https://www.econbiz.de/10005590457
Whereas individual cost-effectiveness analyses of new agents for acute leukaemia should be performed in target populations, any meaningful pharmacoeconomic evaluation of treatment options for this condition should include the many types of costs and outcomes in unselected, representative groups...
Persistent link: https://www.econbiz.de/10005590509
justifiable in terms of the mortality and morbidity gains associated with the new lower-risk NSAIDs. …
Persistent link: https://www.econbiz.de/10005590543
Background— Women with acute myocardial infarction have a higher hospital mortality rate than men. This difference has … study is to assess these factors in relation to excess mortality in women. Methods and Results— All hospital admissions in … regression on mortality was performed for age, comorbidities, and coronary interventions. Nonparametric microsimulation models …
Persistent link: https://www.econbiz.de/10008790069