Response surface experiments often involve only quantitative factors, and the response is fit using a full quadratic model in these factors. The term response surface implies that interest in these studies is more on prediction than parameter estimation since the points on the fitted surface are...

Many industrial experiments involve one or more restrictions on the randomization. In such cases, the split-plot design structure, in which the experimental runs are performed in groups, is a commonly used cost-efficient approach that reduces the number of independent settings of the...

In many industrial experiments, complete randomization of the runs is impossible as, often, they involve factors whose levels are hard or costly to change. In such cases, the split-plot design is a cost-efficient alternative that reduces the number of independent settings of the hard-to-change...

In this paper the estimation problem and the problem of designing experiments in a nonlinear regression model, used in microbiology, are studied. The model is called Monod model, defined imlicitly by a differential equation for the regression function and has numerous applications in microbial...

Designed experiments allow researchers to explore and understand the relation between sets of experimental factors and one or more responses. However, there are many cases where the experimenter cannot determine the factor levels freely. In this article, we study a baking experiment where the...

In industrial experimentation there is growing interest in studies that span more than one processing step. Convenience often dictates restrictions in randomization in passing from one processing step to another. When the study encompasses three processing steps, this leads to split-split-plot...

We introduce a new method for generating optimal split-plot designs. These designs are optimal in the sense that they are efficient for estimating the fixed effects of the statistical model that is appropriate given the split-plot design structure. One advantage of the method is that it does not...