We build a cumulative innovation model in which both success and failure provide valuable information for future research. To test this learning mechanism, we use a dataset covering outcomes of world-wide R&D projects in the pharmaceutical industry, and proxy knowledge flows with forward...

This Study provides an analytical overview of the state of the European Union medical device industry with regard to the following aspects: a) the impact of innovation in medical devices on health costs and expenditure; b) the innovativeness of the European medical device industry; c) the...

La letteratura suggerisce che l'applicazione del reference pricing avvenga solo sugli off-patent, sulla base di cluster chimico-terapeutico-biologici, con prezzo di rimborso allineato a quello del prodotto più economico. Non mancano, tuttavia, segnalazioni di criticità, riconducibili alle...

Si presenta la prima versione di FarmaRegio, modello econometrico per l'analisi della variabilità regionale della spesa farmaceutica territoriale convenzionata (un panel ad effetti casuali). Si suggeriscono due prospettive di lettura: da un lato, la valutazione della significatività delle...

Le malattie rare, che colpiscono pochi pazienti nei Paesi sviluppati nonché quelle dimenticate del Terzo Mondo, rappresentano la nuova frontiera della ricerca biomedica, una delle sfide più pressanti alla globalizzazione dei diritti dei malati, e anche un'importante occasione di crescita...

The pharmaceutical industry is a textbook example of a science based sector characterized by high R&D cost, uncertain and spillovers for which patent protection assures appropriability thus providing incentives for innovation. Indeed, Mansfield (1986) found that, absent patent protection, 60...

This paper investigates patterns of industrial dynamics and competition in the pharmaceutical industry, with particular reference to the consequences of patent expiry in different countries. We focus on the competition at the level of single chemical entities, distinguishing between original...

The prominent role played by patents within the pharmaceutical domain is unquestionable. In this paper we take an unusual perspective and focus on a relatively neglected implication of patents: the effect of patent-induced information disclosure (of both successes and failures) on the dynamics...