An empirical Bayes approach is proposed as a means of utilizing historical control information in modelling the relationship between the level of exposure to the test agent and the rate of tumour occurrence in carcinogenicity bioassays. Using a simple two-parameter linear logistic model, it is...

We propose a Poisson modelling approach to random effects Cox proportional hazards models. Specifically we describe methods of statistical inference for a class of random effects Cox models which accommodate a wide range of nested random effects distributions. The orthodox BLUP approach to...

To better understand how health risks are conceptualised by the Canadian public, exploratory and confirmatory factor analytic techniques were applied to data from a recent national telephone survey on health risk perception (N = 1503). Hazards assessed comprised an array of 30 items selected a...