We use ideas from estimating function theory to derive new, simply computed consistent covariance matrix estimates in nonparametric regression and in a class of semiparametric problems. Unlike other estimates in the literature, ours do not require auxiliary or additional nonparametric regressions.

There are three major points to this article: 1. Measurement error causes biases in regression fits. The line one would obtain if one could accurately measure exposure to environmental lead media will differ in important ways when one measures exposure with error. 2. The effects of measurement...

Stuetzle and Mittal (1979) for ordinary nonparametric kernel regression and Kauermann and Tutz (1996) for nonparametric generalized linear model kernel regression constructed estimators with lower order bias than the usual estimators, without the need for devices such as second derivative...

Epidemiologists sometimes study the association between two measures of exposure on the same subjects by grouping the data into categories that are defined by sample quantiles of the two marginal distributions. Although such grouped data are presented in a twoway contingency table, the cell...

Estimating equations have found wide popularity recently in parametric problems, yielding consistent estimators with asymptotically valid inferences obtained via the sandwich formula. Motivated by a problem in nutritional epidemiology, we use estimating equations to derive nonparametric...

In many regression applications both the independent and dependent variables are measured with error. When this happens, conventional parametric and nonparametric regression techniques are no longer valid. We consider two different nonparametric techniques, regression splines and kernel...

In this paper we consider the polynomial regression model in the presence of multiplicative measurement error in the predictor. Consistent parameter estimates and their associated standard errors are derived. Two general methods are considered, with the methods differing in their assumptions...

Functional data analysis (FDA) is an active field of statistics, in which the primary subjectsin the study are curves. My dissertation consists of two innovative applications offunctional data analysis in biology. The data that motivated the research broadened thescope of FDA and demanded new...

This dissertation consists of five independent projects. In each project, a novelstatistical method was developed to address a practical problem encountered in genomiccontexts. For example, we considered testing for constant nonparametric effectsin a general semiparametric regression model in...

Semiparametric regression has become very popular in the field of Statistics over theyears. While on one hand more and more sophisticated models are being developed,on the other hand the resulting theory and estimation process has become more andmore involved. The main problems that are...