An important problem in microarray experiments is the detection of genes that are differentially expressed in agiven mumber of classes. We consider a straightforward and easily implemented method for estimating the posterior probability that an individual gene is null. The problem can be...

Nonparametric estimation of the conditional mean function for additive models is investigated in cases where the observed data are dependent. We use an additive kernel estimator which is a sum of Nadaraya--Watson estimators. Under a strong mixing condition, the kernel estimator is shown to be...

Diagnosis based on medical image data is common in clinical research and clinical routine. We discuss a strategy to derive a classifier with good performance on clinical image data and to justify the properties of the classifier by an adapted simulation model of image data. As learning set we...

The construction of simple classification rules is a frequent problem in medical research. For example a difference in overall survival time may suggest distinct types, i.e. subgroups of patients, of diffuse large B-cell lymphoma identified by gene expression profiling. Maximally selected rank...

The combination of classifiers leads to substantial reduction of misclassification error in a wide range of applications and benchmark problems. We suggest to use the out-of-bag sample for combining different classifiers. In our setup, a Linear Discriminant Analysis is performed using the...