Aim: To establish whether universal vaccination of infants with the pneumococcal conjugate vaccine is likely to be cost-effective from the perspective of the: health care provider (NHS). Method: Two hypothetical cohorts - one vaccinated and one unvaccinated - were followed over their lifetime....

Aims/hypothesis: the cost-effectiveness of eight strategies for screening for gestational diabetes (including no screening) was estimated with respect to the level of individual patient risk. Methods: cost–utility analysis using a decision analytic model populated with efficacy evidence...

Bootstrapping is used to estimate the effectiveness of different vaccination strategies for rubella in England and Wales. It is assumed that rubella infection follows the deterministic age-structured model discussed by Dietz and Schenzle (1985). The bootstrap is used to estimate percentile...

This dissertation deals with two important research problems in computer networks: resource allocation and caching. It consists of three essays in the broad research areas mentioned above. Essay 1 presents a pricing and allocation mechanism for peer-to-peer (P2P) networks. A P2P system can be...

We introduce a new model for the interaction of immunological cells that takes into account their location in real space. Each one of the model cells mimics the real B cells in the sense that they detect antigens and they are also capable of reproducing themselves. We perform computer...

Laboratories have historically been under supported in developing country health systems resulting in poor quality diagnosis and inadequate disease surveillance. Laboratory professionals are predominantly male with relatively limited female labor participation, with potential gender based...

AIDS is the pandemic of our era. A disease that scares us not only because it is fatal but also because its insidious time course makes us all potential carriers long before it hands us our heads in a basket. The strange three stage dynamics of aids is also one of the major puzzles while...