In this article, we describe a new software for modeling correlated binary data based on orthogonalized residuals (Zink and Qaqish, 2009), a recently developed estimating equations approach that includes, as a special case, alternating logistic regressions (Carey et al., 1993). The software is...

Deletion diagnostics are introduced for the regression analysis of clustered binary outcomes estimated with alternating logistic regressions, an implementation of generalized estimating equations (GEE) that estimates regression coefficients in a marginal mean model and in a model for the...

The receiver operating characteristic (ROC) curve may be used to evaluate the performance of a biomarker measured on continuous scale to predict disease status or clinical condition. Motivated by the need for novel study designs with better estimation efficiency and reduced study cost, we...

The conventional approach of choosing sample size to provide 80% or greater power ignores the cost implications of different sample size choices. Costs, however, are often impossible for investigators and funders to ignore in actual practice. Here, we propose and justify a new approach for...

The area under a ROC curve (AUC) and partial area under a ROC curve (pAUC) are important summary measures useful in assessing the accuracy of a diagnostic test or a biomarker in discriminating true disease status. We consider nonparametric estimation of AUC and pAUC under a test-result-dependent...