Purpose One of the most important uses of benefit-risk assessment pertains to approval of new medicines by regulatory authorities and the subsequent review of these products during their life-cycle when new safety and/or efficacy data becomes available. At present, there exist no validated,...

This paper investigates the determinants of the prices of branded prescription medicines across different regulatory settings and health care systems, taking into account their launch date, patent status, market dynamics and the regulatory context in which they diffuse. By using volume-weighted...

Pharmacoeconomic analyses have become useful and essential tools for health care decision makers who increasingly require such analyses prior to placing a drug on a national, regional or hospital formulary. Previous health economic models of non-steroidal anti-inflammatory drugs (NSAIDs) have...

Objective To determine the cost effectiveness of selected malaria control interventions in the context of reaching the millennium development goals for malaria. Design Generalised cost effectiveness analysis. Data sources Efficacy data came from the literature and authors' calculations supported...

Objective: There is a growing literature on the relationship between teamwork and patient outcomes in intensive care, providing new insights into the skills required for effective team performance. The purpose of this review is to consolidate the most robust findings from this research into an...

The present study explores the relationship between perceived organizational support and health support from supervisors and workmates, and ‘safety citizenship behaviour’ (SCB) in offshore employees. It is hypothesised that high levels of support reflecting care in the organization about...

Cancer incidence data for the Ontario Public Health Units in 1980-91 were examined to investigate regional patterns and the existence of outlier values after adjustment for known risk factors. Candidate risk factors were derived from the Ontario Health Survey and the census. Weighted regressions...

The numbers of quality-adjusted life years (QALYs) gained are increasingly being used to represent the gains in individual utility from treatment. This requires that the value of a health improvement to an individual is a simple product of gains in quality of life and length of life. The article...

Since the National Health Service reforms were introduced, the NHS has moved towards a greater emphasis on accountability and efficiency of healthcare. These changes rely on the swift delivery of IT systems, implemented into the NHS because of the urgency to collect data to support these...

BACKGROUND: As the health care economic-evaluation literature continues to grow, a need for sound methods to conduct systematic reviews of the existing evidence is emerging. So far, reviews of economic evaluations have relied upon noncomprehensive sources and have adopted simplistic search...