In canonical vector time series autoregressions, which permit dependence only on past values, the errors generally show contemporaneous correlation. By contrast structural vector autoregressions allow contemporaneous series dependence and assume errors with no contemporaneous correlation. Such...

In the finance literature, cross-sectional dependence in extreme returns of risky assets is often modelled implicitly assuming an asymptotically dependent structure. If the true dependence structure is asymptotically independent then current modelling approaches will lead to an over-estimation...

There is currently great interest in understanding the way in which recombination rates vary, over short scales, across the human genome. Aside from inherent interest, an understanding of this local variation is essential for the sensible design and analysis of many studies aimed at elucidating...

There is evidence to suggest that the effects of behavioral interventions may be limited to specific types of individuals, but methods for evaluating such outcomes have not been fully developed. This study proposes the use of finite mixture models to evaluate whether interventions, and,...

Pharmacokinetic studies are commonly analyzed using a two-stage approach where the first stage involves estimation of pharmacokinetic parameters for each subject separately and the second stage uses the individual parameter estimates for statistical inference. This two-stage approach is not...

We consider the problem of semi-parametric regression modelling when the data consist of a collection of short time series for which measurements within series are correlated. The objective is to estimate a regression function of the form E[Y(t) | x] =x'ß+μ(t), where μ(.) is an arbitrary,...

Marginal models for multivariate binary data permit separate modelling of the relationship of the response with explanatory variables, and the association between pairs of responses. When the former is the scientific focus, a first-order generalized estimating equation method (Liang & Zeger,...

Distinguishing between the confounding effects of temporal dependence, variation in exogenous factors and residual heterogeneity over and above that due to measured explanatory variables is a major challenge to be confronted in any analysis of panel or similar longitudinal data. This paper...

Pharmacokinetic studies are commonly analyzed using a two-stage approach where the first stage involves estimation of pharmacokinetic parameters for each subject separately and the second stage uses the individual parameter estimates for statistical inference. This two-stage approach is not...

Quantile regression is applied in two retail credit risk assessment exercises exemplifying the power of the technique to account for the diverse distributions that arise in the financial service industry. The first application is to predict loss given default for secured loans, in particular...