For the compartmental model we determine optimal designs, which are robust against misspecifications of the unknown model parameters. We propose a maximin approach based on D-efficiencies and provide designs that are optimal with respect to the particular choice of various parameter regions.

In this paper robust and efficient designs are derived for several exponential decay models. These models are widely used in chemistry, pharmacokinetics or microbiology. We propose a maximin approach, which determines the optimal design such that a minimum of the D-efficiencies (taken over a...

The problem of determining optimal designs for least squares estimation is considered in the common linear regression model with correlated observations. The approach is based on the determination of ‘nearly’ universally optimal designs, even in the case where the universally optimal design...

A class of multiplicative algorithms for computing D-optimal designs for regression models on a finite design space is discussed and a monotonicity result for a sequence of determinants obtained by the iterations is proved. As a consequence the convergence of the sequence of designs to the...