Showing 71 - 80 of 251
We consider a class of optimality criteria and show that each crite- rion has its unique and equivalent dual within the class. This property can be used to find a variety of optimal designs, including a class of compound optimal designs and their relationships. As an example, we show that one...
Persistent link: https://www.econbiz.de/10010296610
This paper investigates the use of Design of Experiments in observational studies in order to select informative observations and features for classification. D-optimal plans are searched for in existing data and based on these plans the variables most relevant for classification are determined....
Persistent link: https://www.econbiz.de/10010296708
The Monod model is a classical microbiological model much used in microbiology, for example to evaluate biodegradation processes. The model describes microbial growth kinetics in batch culture experiments using three parameters: the maximal specific growth rate, the saturation constant and the...
Persistent link: https://www.econbiz.de/10010296747
We consider nested multiple response models which are used extensively in the area of pharmacometrics. Given the conditional nature of such models, differences in predicted responses are a consequence of different assumptions about how the models interact. As such, sequential versus simultaneous...
Persistent link: https://www.econbiz.de/10009448496
The aim of this paper is to derive methodology for designing 'time to event' type experiments. In comparison to estimation, design aspects of 'time to event' experiments have received relatively little attention. We show that gains in efficiency of estimators of parameters and use of...
Persistent link: https://www.econbiz.de/10009448497
A simplex-centroid design for q mixture components comprises of all possible subsets of the q components, present in equal proportions. The design does not contain full mixture blends except the overall centroid. In real-life situations, all mixture blends comprise of at least a minimum...
Persistent link: https://www.econbiz.de/10011995823
Persistent link: https://www.econbiz.de/10005375770
Persistent link: https://www.econbiz.de/10005395637
Persistent link: https://www.econbiz.de/10005395754
In this paper we show how techniques from response surface methodology and mathematical programming can be combined into a new sequential derivative-free approach for solving unconstrained deterministic black-box optimization problems.In this sequential derivative-free optimization approach...
Persistent link: https://www.econbiz.de/10011091046