In this article a new monotone nonparametric estimate for a regression function of two or more variables is proposed. The method starts with an unconstrained nonparametric regression estimate and uses successively one-dimensional isotonization procedures. In the case of a strictly monotone...

To estimate the effective dose level ED a in the common binary response model, several parametric and nonparametric estimators have been proposed in the literature. In the present paper, we focus on nonparametric methods and present a detailed numerical comparison of four different approaches to...

In this article a new monotone nonparametric estimate for a regression function of two or more variables is proposed. The method starts with an unconstrained nonparametric regression estimate and uses successively one-dimensional isotonization procedures. In the case of a strictly monotone...

To estimate the effective dose level ED a in the common binary response model, several parametric and nonparametric estimators have been proposed in the literature. In the present paper, we focus on nonparametric methods and present a detailed numerical comparison of four different approaches to...

In this article a new monotone nonparametric estimate for a regression function of two or more variables is proposed. The method starts with an unconstrained nonparametric regression estimate and uses successively one-dimensional isotonization procedures. In the case of a strictly monotone...

We consider the design problem for the estimation of several scalar measures suggested in the epidemiological literature for comparing the success rate in two samples. The designs considered so far in the literature are local in the sense that they depend on the unknown probabilities of success...

In this paper we describe the special role of moment theory for the construction of optimal designs in statistical regression models. A careful introduction in the problem of designing experiments for certain polynomial regression models is given, and it is demonstrated that the maximization of...