The correlated Weibull regression model for the analysis of correlated binary data is presented. This regression model is based on Bonney’s disposition model for the regression analysis of correlated binary outcomes. Parameter estimation was done through the maximum likelihood method. The...

Microarrays are part of a new class of biotechnologies which allow the monitoring of expression levels of thousands of genes simultaneously. In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting...

The protein family of septins is analyzed with the SOM methodology of Andrade et al. (1997) to determine the family relationships and the key residues responsible for the obtained classification. These key residues are candidates for determining functional sites of the proteins. The advantages...

Microarrays are part of a new class of biotechnologies which allow the monitoring of expression levels of thousands of genes simultaneously. In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting...

In this paper, hidden Markov models (HMMs) are discussed in the context of molecular biological sequence analysis. The statistics relevant in the HMM approach are described in detail. An HMM based method is used to analyze two proteins that contain short protein repeats (SPRs). As a benchmark, a...

These report presents two methods for the identification of signal peptides and their cleavage sites. The first method is based on based neural networks and the second on hidden Markov models. The transmembrane protein topology can also be identified by a method based on hidden Markov models,...

In the present study we investigate the data provided by the karstwater level monitoring system set up in the Transdanubian Mountains, more precisely in the Bakony, the Keszthelyi Mountains and the Balaton-Highland. (Here, like in the sequel, the term karstwater is used for groundwater in...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It’s a first step to analyse the processes which are involved in the development of DNA adducts and might therefore lead to the development of cancer. The complete...

The determination of toxicokinetic parameters is an essential component in the risk assessment of potential harmful chemicals. It is a key step to analyse the processes involved in the formation of DNA adducts which are connected with the development of chemical-induced cancer. A general problem...