In pharmaceutical R&D, decision makers face a large portion of uncertainty in portfolio decisions. Existing optimization tools are mostly based on expected values, ignoring uncertainty, and most often deliver a single, "best" selection of projects. A decision tree approach can aid decision...

This paper aims to gain insight into capacity allocation, downsizing decisions and sequencing rules when managing a portfolio of projects. By downsizing, we mean reducing the scale or size of a project and thereby changing the project's content. In previous work, we have determined the amount of...