We consider problems of quantifying and monitoring accuracy and precision of measurement in mass spectrometry, particularly in contexts where there is unavoidable day-to-day/period-to-period changes in instrument sensitivity. First we consider the issue of estimating instrument sensitivity based...

There is a little-known but very simple generalization of the standard result that for uncorrelated variables with a common mean and variance, the expected sample variance is the marginal variance. The generalization justifies the use of the usual standard error of the sample mean in possibly...

Most standard statistical methods treat numerical data as if they were real (infinitenumber- of-decimal-places) observations. The issue of quantization or digital resolution is recognized by engineers and metrologists, but is largely ignored by statisticians and can render standard statistical...

In this note we examine the relevance of Sheppard's correction for variances and (both the original and a valid weak form of) the so-called 'quantization noise model' to understanding the effects of integer-rounding on continuous random variables. We further consider whether there is any real...

In this entry we seek to put into perspective some of the ways in which statistical methods contribute to modern engineering practice. Engineers design and oversee the production, operation, and maintenance of the products and systems that under-gird modern technological society. Their work is...

We consider likelihood and Bayes analyses for the symmetric matrix von Mises-Fisher (matrix Fisher) distribution, which is a common model for three-dimensional orientations (represented by 3x3 orthogonal matrices with a positive determinant). One important characteristic of this model is a 3x3...

We treat situations in which independent structurally identical decision problems are to be faced either simultaneously or serially. Recent work on such compound decision problems has centered on finding procedures that satisfy the strengthened asymptotic optimality property of Gilliland and...