In some commonly used longitudinal clinical trials designs, the quadratic inference functions (QIF) method fails to work due to non-invertible estimation of the optimal weighting matrix. We propose a modified QIF method, in which the optimal weighting matrix is estimated by a linear shrinkage...

The additive hazard regression (AHR) model is known for its convenience in interpretation, as hazard is modeled as a linear function of covariates. One outstanding issue in the application of such a model in the analysis of current status data is that there lacks an efficient and computationally...

This paper proposes a new time-deformation model for stock returns sampled in transaction time and directed by a generalized duration process. Stochastic volatility in this model is driven by an observed duration process and a latent autoregressive process. Parameter estimation in the model is...