Technological advances make it possible to use high-throughput sequencing as a primary discovery tool of medical genetics, specifically for assaying rare variation. Still this approach faces the analytic challenge that the influence of very rare variants can only be evaluated effectively as a...

This is a seminar based on research literature. Papers covered are selected to illustrate important problems and approaches in the field of computational and systems biology, and provide students a framework from which to evaluate new developments. The MIT Initiative in Computational and Systems...

Research on happiness has produced valuable insights into the sources of subjective well-being. A major finding from this literature is that people exhibit a "baseline" happiness that shows persistent strength over time, and twin studies have shown that genes play a significant role in...

Recent years have seen astonishing advances in technology and explosions of data in biopharmaceutical R&D, which are driving two waves of change to the industry[...]