In this article we explore the testing of non-inferiority and equivalence hypotheses arising from multiple centers when the assumption of normality is violated. In a multicenter study, the trials are typically conducted at different centers which vary in terms of location, environment,...

According to the American Cancer Society report (1999), cancer surpasses heart disease as the leading cause of death in the United States of America (USA) for people of age less than 85. Thus, medical research in cancer is an important public health interest. Understanding how medical...