Mutualisms provide benefits to those who participate in them. As a mutualism evolves, how will these benefits come to be allocated among the participants? We approach this question using evolutionary game theory and explore the ways in which the coevolutionary process determines the allocation...

Do proteins with larger fluctuations in their functions show higher rates of their evolutions? To gain some insight on the question, we conducted an in vitro experimental evolution where a mutant of green fluorescence protein (GFP) with random sequence at its N terminus was subjected to ten...

Abstract A common goal of epidemiologic research is to study the association between a certain exposure and a certain outcome, while controlling for important covariates. This is often done by fitting a restricted mean model for the outcome, as in generalized linear models (GLMs) and in...

In this thesis, we propose to analyze panel count data using a spline-basedsieve generalized estimating equation method with a semiparametric proportional mean model E(N(t)|Z) = Λ0(t) eβT0Z. The natural log of the baseline mean function, logΛ0(t), is approximated by a monotone cubic B-spline...

This research develops a framework to estimate the effective sample size of Global Positioning System (GPS) based panel surveys in urban travel behavior studies for a variety of planning purposes. Recent advances in GPS monitoring technologies have made it possible to implement panel surveys...