Background: There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a not insignificant risk of undesirable effects. Objective and methods: In the randomized, prospective clinical...

For testing one-sided but also two-sided hypotheses concerning several treatment arms in group sequentially performed clinical trials with arbitrary outcome variables, a general learning method is considered that allows for a complete self-designing of the study. All information available prior...

In combining several tests of significance the individual test statistics are allowed to be dependent. By choosing the weighted inverse normal method for the combination, the dependency of the original test statistics is then characterized by a correlation of the transformed statistics. For this...

Die Umsetzung der Richtlinie zur Bestimmung der Anzahl von anorganischen faserförmigen Partikeln auf staubbelegten Filtern wurde in einem Ringversuch von VDI und DIN überprüft. Die Auswertung der Filter wurde zunächst in zwei Referenzlabors und danach in den teilnehmenden Prüflabors...

In many applications we obtain test statistics by combining estimates from different experiments or studies. The usual combined estimator of the overall effect in independent studies leads to systematic overestimates of the significance level, see Li et al. (1994). This results in a great number...

Sind in einer statistischen Analyse mehr als eine Variationsursache zu berücksichtigen_ so zerfällt die Gesamtvariation in mehrere Komponenten. Für diese sind in der Regel auch Beziehungen oder Ordnungen bekannt. Aber keine der bekannten Schätztheorien ist in der Lage, diese Ordnungen auch...

A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full...

Different estimation methods for covariance parameters in meta-analyses can result in conflicting p-values concerning the test of treatment effect. We propose a valid method to overcome this problem at least partially by introducing a new estimator for the standard deviation of the common...

In many fields of applications, test statistics are obtained by combining estimates from several experiments, studies or centres of a multicentre trial. The commonly used test procedure to judge the evidence of a common overall effect can result in a considerable overestimation of the...