Alliance formation is commonplace in many high-technology industries experiencing radical technological change, where established firms use alliances with new entrants to adapt to technological change, while new entrants benefit from the ability of established players to commercialize the new...

This paper studies how pharmaceutical research and development (Ramp;D) investment responds to publicly supported biomedical research performed mainly in universities and non-profit institutions. New micro-level data on investment by the U.S. National Institutes of Health allow measures of...

Knowledge diffusion drives both technical progress and economic growth. In this study, we present a unique comparative case study that examines the diffusion of two comparable, foundational biotechnology inventions – recombinant DNA (rDNA) and polymerase chain reaction (PCR). Using a variety...

The high cost of capital for firms conducting medical research and development (R&D) has been partly attributed to the government risk facing investors in medical innovation. This risk slows down medical innovation because investors must be compensated for it. We propose new and simple financial...

This study focused on two primary areas: 1. To determine what can be learned from biotech and drug development companies that suffered from financial problems and ultimately failed at the beginning of the 21st century. 2. To determine how intellectual capital developed in accordance with such...

The thesis puts forth an empirical methodology to study the link between modes of knowledge production and innovation, based on a functional (basic research, applied research and development) and organisational (internal research, external research) analysis of RD activities. To do so, it uses...

Research on intellectual property has focused on formal legally recorded rights that we call deeded, most often measured by granted patents. Meanwhile, other "defacto" IP (mainly purposive secrecy and natural excludability) has become more important because of the increasing closeness of...

This paper analyses the inter-firm R&D network formed in the pharmaceutical biotechnology industry during the 1990s from different perspectives: theoretical network formation, firm's structural positions and its collaborations at the entire network level, and the determinants for firm's...

Even though management consultants increasingly recommend that in-house research be outsourced, little is known about the conditions favoring substitution or complementarity between internal R&D and external technology acquisition. In this paper, we attempt to provide a deeper understanding of...