Discrete breathers are time-periodic spatially localised motions in networks of oscillators. Their occurrence in three principal contexts is reviewed: (i) autonomous Hamiltonian or reversible systems, (ii) autonomous forced damped systems, and (iii) time-periodically forced systems. The main...

A mechanism for relationship of solvent viscosity with reaction rate constant at enzyme action is suggested. It is based on fluctuations of electric field in enzyme active site produced by thermally equilibrium rocking (crankshaft motion) of the rigid plane (in which the dipole moment ≈3.6D...

Identification of proton-conducting pathways in a protein is a key to understanding the mechanisms of biomolecular proton transfer. Starting from a known protein structure, proton pathways are modeled here as hydrogen bonded networks of proton conducting groups, including proton-exchanging...

Statistical theory of any physical process needs a formulation of possibly simple but adequate models of the phenomena underlying microscopic dynamics. Remarkable progress in studies of internal dynamics of biomolecules acomplished in the recent years has made it possible to formulate such...

Molecular dynamics simulations of plastocyanin, an electron transfer copper containing protein involved in the photosynthetic process, have been performed in both the hydrated and dry state. An analysis of the potential energy fluctuations during a 500 ps dynamical evolution of the macromolecule...

It is argued that the actomyosin motor can be effectively considered a common chemo-chemical enzymatic machine occurring, however, in multitude rather than a few conformational substates distinguished by the conventional kinetics. A technique was developed with the help of which relations were...

Protein activities may exhibit oscillations which often occur due to the existence of a negative feedback loop with an effective time delay. Many biological systems are, however, not limited to one feedback loop but consist of multiple loops on different regulatory levels. Here, we analyze the...