We present two dynamical models for the appearance of adaptive mutations, which permit a quantitative comparison with experimental observations. The models quantify two alternative pictures: The hyper-mutating sub-population picture, and the population-wide mutation picture. We find that both...

A novel approach was developed to form engineered, electrically viable, neuronal networks, consisting of ganglion-like clusters of neurons. In the present method, the clusters are formed as the cells migrate on low affinity substrate towards high affinity, lithographically defined carbon...

The colonial communication, regulation and control during colonial development justify the notion of smart bacteria. Had we demonstrated colonial adaptive morphogenesis resulting from environmental stress on the colony, it would provide strong support to the notion of “bacterial wisdom”.

We present a diffusion-transition scheme to study the penetration of a stable phase into a meta-stable one in systems described by a conserved order parameter. This approach is inspired by the specific example of solidification from supersaturated solution, for which we can take advantage of new...

Bacteria have developed intricate communication capabilities on all levels—the genome, the individual bacteria, the colony, and multi-colonial eco-systems of different bacterial species. All manner of biochemical messages are utilized for communication, including simple and complex abiotic...

All kinds of hypotheses have been proposed to explain the mechanism of tumorigenesis. Up until now, we have not had any generally acknowledged model that helps us understand the process. However, it is well accepted that cancer development and progression is dictated by a series of alterations...

We propose a new picture of the genome as an adaptive cybernetic unit with self-awareness. We further propose that under colonial stress bacteria employ genetic communication which leads to the emergence of creative genomic web or “global brain”.

One of the main challenges facing biology today is the understanding of the joint action of genes, proteins and RNA molecules, interwoven in intricate interdependencies commonly known as genetic networks. To this end, several mathematical approaches have been introduced to date. In addition to...

This paper is devoted to presenting an alternative approach to the Darwinian one. The basic assumption is that the creativity observed in nature is not an illusion but part of an objective reality. In the new picture evolutionary progress is not a result of successful accumulation of mistakes,...

The spontaneous activity of cultured in vitro neuronal networks exhibits rich dynamical behavior. Despite the artificial manner of their construction, the networks’ activity includes features which seemingly reflect the action of underlying regulating mechanism rather than arbitrary causes and...