‘Noncompliant’ (NC) patient is a common label in medical records. While it encapsulates many dimensions of undesired patient behavior, the semiotics by which it is generated and applied is unclear: What data indicate noncompliance? How are the data analyzed and interpreted to label a patient...

The 'e' in eBusiness, eCommerce, eGovernment, and eHealth represents the transformation of the traditional domains by the current ability to transport information using information and communication technologies. In this paper we present an ontological analysis of the transformation of health...

Clinical and Translational Science (CTS) is a new and emerging academic discipline which seeks to reduce (a) the time-to-application of research to, and (b) the time-to-research of, health care problems. Translating information within and between the research and practice silos is central to...

The dotcom strategies, as a class, may be called experimental-radical strategies. Experimental, as opposed to logical: willing to act without the guidance of theory. Radical, in contrast to incremental: breaking with the past. The counterpoint to the dotcom strategies, the traditional...

A primary goal of terrorism is to instill a sense of fear and vulnerability in a population and to erode its confidence in government and law enforcement agencies to protect citizens against future attacks. In recognition of its importance, the Department of Homeland Security includes public...

This paper presents a comprehensive socio-technical framework for the design and development of a Clinical and Translational Science Informatics Infrastructure (CTSII). Based on our experience with developing and applying the framework we present a case study to illustrate the issues that arise...