This doctoral dissertation is composed of three projects and four chapters. Chapter 1 presents the background theories and models in the field of population genetics that are related to these projects.In Chapter 2, I develop a composite likelihood ratio test (CLRT) for detecting genes and...

In recent decades, digital technologies have seriously changed socioeconomic systems on a global scale. Unfortunately, consequential issues have remained mostly uninvestigated. The literature lacks research into the risks that may arise in the procedure of developing digital capabilities that...

Canine hip dysplasia (CHD) is characterized by hip laxity and subluxation that can lead to hip osteoarthritis. Studies have shown the involvement of multiple genetic regions in the expression of CHD. Although we have associated some variants in the region of fibrillin 2 with CHD in a subset of...

The aims of this study were to undertake principal component analysis (PCA) of hip dysplasia (HD) and to examine the power of the principal components (PCs) in genome-wide association studies. A cohort of 278 dogs for PCA and that of 369 dogs for genotyping were used. The distraction index (DI),...

Front Distribution Centre (FDC) is a new terminal warehouse which is closer to customer, and its location selection is crucial for e-commerce and customer time satisfaction. We introduce in this paper a joint distribution function of demand based on time and space and design a staged clustering...

Wastewater generated from N-methylpyrrolidone (NMP) manufacture was used as electron donor for denitrification in tertiary treatment. The organic components of NMP wastewater were mainly NMP and monomethylamine (CH3NH2), and their biodegradation released ammonium that was nitrified to nitrate...

A new procedure is proposed to balance typeI andII errors in significance testing for differential expression of individual genes. Suppose that a collection, , of k lists of selected genes is available, each of them approximating by their content the true set of differentially expressed genes....