The Bayesian continual reassessment method (CRM) and its likelihood version (CRML) provide important tools for the design of Phase I cancer clinical trials. However, a poorly chosen prior distribution in CRM may lead to inferior performance of the method in the early stage of a trial, whereas...

In this work, heat production potential from hot dry rock by water circulating through two horizontal wells was numerically investigated based on the geological data of well DP23-1 under the enhanced geothermal system (EGS) project at Desert Peak geothermal field. The results indicate that the...

In a sequential clinical trial whose stopping rule depends on the primary endpoint, inference on secondary endpoints is an important long-standing problem. Ignoring the possibility of early stopping based on the primary endpoint may result in substantial bias. To address this problem, a commonly...

We propose an adaptive importance resampling algorithm for estimating bootstrap quantiles of general statistics. The algorithm is especially useful in estimating extreme quantiles and can be easily used to construct bootstrap confidence intervals. Empirical results on real and simulated data...

We examine the effects of shocks in the oil market on key macroeconomic variables in small open economies using a dynamic stochastic general equilibrium model with sticky prices and imperfect competition under different monetary policy rules. The numerical solutions show that the types of...