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-simplifying optimization techniques need to be employed. General methods for simulation optimization that do not inhibit system … economists. This paper describes the theory and algorithm of a robust and efficient simulation optimization approach, the Complex …
Persistent link: https://www.econbiz.de/10005790632
Phage display, SELEX and other methods of combinatorial chemistry have become very popular means of finding ligands with high affinities to given targets. Despite their success, they suffer from numerous sources of error and bias, such as very low initial concentrations of species, non-specific...
Persistent link: https://www.econbiz.de/10005790639
Highly optimized tolerance is a model of optimization in engineered systems, which gives rise to power …
Persistent link: https://www.econbiz.de/10005790761
evolutionary optimization. …
Persistent link: https://www.econbiz.de/10005790850
Technological change at the firm level has commonly been modeled as random sampling from a fixed distribution o f possibilities. Such models, however, typically ignore empirically important aspects of the firm's search process, notably the observation that the present state of the firm guides...
Persistent link: https://www.econbiz.de/10005791001
the dynamics of the optimization process. This results in a non-linear relation between the fraction of tertiary … results have important implications for evolutionary optimization in biopolymers, in particular the evolution of viruses. …
Persistent link: https://www.econbiz.de/10005791065
Army ant colonies display complex foraging raid patterns involving thousands of individuals communicating through chemical trails. In this paper we explore, by means of a simple search algorithm, the properties of these trails in order to test the hypothesis that their structure reflects an...
Persistent link: https://www.econbiz.de/10005791067
Purpose This paper aims to suggest alternative suspicious activity analyses to improve the focus of financial institution reporting to law enforcement and to identify some limitations in the current practice. Design/methodology/approach This paper employs the consideration of US and Financial...
Persistent link: https://www.econbiz.de/10014866175
The problem of portfolio optimization involves selecting appropriate stocks for investment by maximising the returns … optimization method that suffers from several pitfalls like instability of beta, and are either computation extensive or lead to … sub‐optimal solutions. The present work suggests a heuristics and evolutionary approaches to portfolio optimization. The …
Persistent link: https://www.econbiz.de/10014839899
The globalization of markets and businesses has meant that many companies now consider the world as a potential marketplace. In this changing environment, two crucial decisions taken by companies are time of entry (e.g. whether to enter early or late) and level of involvement (e.g. whether to...
Persistent link: https://www.econbiz.de/10014827203