Concerns about the intrusion of economic and financial considerations into patient management have increased in the United Kingdom, largely as a result of the passage of the 1990 National Health Services Act. Based on an agenda set by the British Medical Association, a questionnaire was designed...

Objective: To assess the cost effectiveness of primary prophylaxis with clotting factor instead of treatment following a bleed (on-demand) for individuals with severe haemophilia. Design: Different data sources on the clinical effects and costs of treatments were combined using a Markov model....

The development of an internal market in UK public sector health care has introduced hard budget constraints for those general practitioner purchasers who elect to hold their own budgets or 'funds'. Prescription medicines constitute an element of the fundholder's budget and a theoretical model...

The utility was higher for the PFS state than baseline, but decreased below baseline in non-response and disease progression states. AEs had an impact on utility within the PFS response state. The severe infection AE had a greater impact on utilities for the responding to treatment state...

<Emphasis Type="Bold">Objective: The aim of the study was to measure the use and estimate the cost of HIV service provision in England. <Emphasis Type="Bold">Design and Setting: Standardised activity and case-severity data were collected prospectively in 10 English HIV clinics (5 London and 5 non-London sites) for the periods 1 January...</emphasis></emphasis>

AIMS: In Spain, the first line treatment of hyperphosphatemia in Chronic Kidney Disease (CKD) consists of calciumbased phosphate binders (CB). However, their use is associated with vascular calcification and an increased mortality risk. The aim of this study was to assess the incremental...