In many randomized trials, subjects enter the sample sequentially. Because the covariates for all units are not known in advance, standard methods of stratification do not apply. We describe and assess the method of DA-optimal sequential allocation (Atkinson, 1982) for balancing stratification...

Purpose: This work aims at providing insights to optimise healthcare logistic of the drug management, in order to deal with the healthcare expenditure cut. In this paper the effects of different drug supply chain configurations, on the resulting average stock, service level and Bullwhip effect,...

Mathematical modeling is a key component of various disciplines in science andengineering. A mathematical model which represents important behavior of a realsystem can be used as a substitute for the real process for many analysis and synthesistasks. The performance of model based techniques,...

The use of computer modeling is fast increasing in almost everyscientific, engineering and business arena. This dissertationinvestigates some challenging issues in design, modeling andanalysis of computer experiments, which will consist of four majorparts. In the first part, a new approach is...

The growth of international markets as well as business partnerships between U.S. and Asian-based firms has lead to an increased interest in an economically viable business jet capable of supersonic cruise and trans-Pacific range with one stop over (or non-stop trans-Atlantic range) 1 . Such an...

Increased rate of use of fossil fuels have greatly polluted the earth through harmful by-products. Biodiesel is an attractive substitute to fossil fuel in compression ignition engine applications. In this research work, vegetable oil namely Arachis Hypogaea Oil (AHO) is used along with ethanol...

In this work, the catalytic upgrading of a bio-oil model compound via esterification with ethanol was studied using 12-tungstosilicic acid as the catalyst. The response surface method was used to investigate and optimize the process variables, which include the ethanol to acid molar ratio,...

The article deals with the use of experimental design in business innovation projects. Firstly, the foundations of experimental design are presented, with special emphasis on the process approach and its applicability in innovation. The second section proposes a guide for its application in...

Randomised controlled or clinical trials (RCTs) are generally viewed as the most reliable method to draw causal inference as to the effects of a treatment, as they should guarantee that the individuals being compared differ only in terms of their exposure to the treatment of interest. This 'gold...

The main objective of this research is to forecast the daily direction of Standard & Poor's 500 (S&P 500) index using an artificial neural network (ANN). In order to select the most influential features (factors) of the proposed ANN that affect the daily direction of S&P 500 (the response),...