In an unbalanced and heteroscedastic one-way random effects model, we compare, by way of simulation, several test statistics for testing the null hypothesis that the variance of the random effects, also named the between group variance, is zero. These tests are the classical F-test, the test...

A class of self-designing clinical trials is considered which according to an effective but simple, finite learning algorithm consists of automatically adaptively planned weighted group sequential trials with a decision about rejection of the null-hypothesis at each step, but the full...