The aim of this paper is to investigate the spatial co-localization in Vietnam of two-digits manufacture industries in 2010. Thus, an exploratory cross-sectional analysis will be conducted using discrete-space models in order to unfold the idiosyncratic patterns of agglomeration, concentration and specialization within the country. The digit code refers to the Vietnam Standard Industrial Classification (VSIC) and 24 manufacturing industries will be included into the research. The information will be collected through the General Statistic Office (GSO) of Vietnam with regard to the firms? output, number of employees and enterprises disaggregated by regions and provinces. In this paper, the Herfindahl-Hirschman index, the locational Gini coefficients, the location quotient, the geographic concentration and the Ellison & Glaeser index will be used in order to explore the agglomeration, concentration and specialization patterns within two-digits manufacturing in Vietnam. The findings of the research show higher co-localization of labor-intensive industries such as manufacture of food, textiles, wearing apparel and leather. Furthermore, it is notable that 70% of firms? output and employment are concentrated in two core regions: the Red River Delta and the South East. It is mainly due to the role played by the two city hubs: Hanoi and Ho Chi Minh. Furthermore, they promote the nearby provincial economies such as Quang Ninh, Hai Phòng, Bình Duong and Dong Nai. However, the presence of numerous industrial zones and governmental industrial policies encourage the business co-localization within the country. For more than twenty years, Vietnam has seen a rapid economic growth and it is one of the most dynamic emerging countries in the South-East Asia. The Vietnamese?s GDP constantly grew with an average of 7% between 2000 and 2012 (World Bank & Donor Working Group, December 06, 2011). Moreover, Vietnam is densely populated and it is characterized by abundant workforce, which favors the establishment of labor-intensive industries (UNIDO & MPI, 2012). The number of total enterprises in Vietnam grew more than 150% between 2005 and 2010, whereas the number of total employment only rose around 60% in the same period of time (General Statistics Office, 2012). This bias can be explainable by an exponential increase of SMEs? start-up and improvement on production efficiency. Furthermore, the inward FDI largely grew more than 200% between 2005 and 2010 (General Statistics Office, 2012). This increase is mainly due to the reduction of barriers to foreign direct investment, as Vietnam became a member of WTO in 2007. These favorable economic conditions inevitably impact on agglomeration, concentration and specialization patterns of business activities within the country. However, there is little academic attention on the Vietnamese economic geography and in particular with reference to the economic aggregation patterns (Ishizuka, 2010).